Erlonat tablets

ERLONAT

• Erlonat   is a drug required for the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer.

Erlonat

Trade name : Tarceva 
Molecular Formula : C22H23N3O4 
Molar mass : N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine. 
Pregnancy category : US.D (evidence of risk) 
Route of administration : Oral tablets. .




Erlonat Indication

Erlonat is also used in combination with gemcitabine( Gemzar) for the treatment pancreatic cancer which has spread to tissues or other parts of the body and which cannot be treated with surgery. 

DOSAGE AND ADMINISTRATION

Pancreatic cancer:dose of 100mg combination with gemcitabine ( 1hr or 2hr after the meal). Necessity of dose adjustment to reduce in 50mg steps. 

Erlonat is studied in patient with severe hepatic impairment. 

Erlonat tablet used on an empty stomach 1hr before or 2hr after the digestion of food. Swallow the tablet via orally. Avoid continues use of proton pump inhibitor with Erlonat tablet. 

Mechanism of Action

In the body, certain cells grow and multiply in a way that is 'out of control' means cancer. Erlonat interfere with the cells grow and increase in number.

SIDE EFFECTS

Serious effects

Rash, dyspnae, fever and chills, chest pressure, dark urine, bloody vomiting, pale or yellow skin, dry mouth, weakness or numbness of an arm or leg.

Symptoms

Head pain, Decreased appetite, Nausea and vomiting, Burn sensation in heart, Athralgia , Myalagia , Darkening of skin,Appearance changes inhair and nails,Hair loss.

DRUG INTERACTION

Reduce exposure of Erlonat tablet by interacting with potent CYP3A4 inhibitor and CYP3A4 inducers. Interaction with increased serum level of potent CYP1A2 inhibitors 
and CYP1A2 inducers causes altered elimination of Erlonat.

Before Taking Erlonat

On treatment of Erlonat, avoid becoming pregnant for a month after final dose. Consult with doctor because Erlonat may affect the fetus. 

Pregnancy & lactation

On treatment with Erlonat, breastfeeding is not recommended because unknown reason in animal milk and affects the nursing infants.

Storage

Erlonat should be store at 25°C.

Do not keep medicine near to the children accessible.

Erlonat store at cool and dry place and protect from light

Missed Dose

if  dose is missed then as sooon as possible take

the dose you remember before next dose otherwise skip the missed,if next dose time reached. Do not take extra dose at a time. Take advice of the doctor about missed dose.


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