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SORAFENIB - 200MG

Define As :

Sorafenib is mechanism by depleting the blood supply to the cancer cells and stop their division and production.  It is not used as curable medicine but Sorafenib is used to reduce the growth rate of cancer cells by barrier the actions of an aberrant protein signal transduction helps to develop the cancer cells. 

The Brands available in sorafenib are 

Dosage :

The Sorafenib Tablets usual dose is 400 mg (2 x 200 mg tablets) 
•Sorafenib administrated twice daily on empty stomach (at least 1 hour before or 2 hours after a meal). 
•The therapy should continue untill the patient is not clinically benefiting from the treatment.

Pharmacology :

This enzyme enhance grow of tumor cells. Sorafenib which will also work as multi kinase inhibitor, Since Sorafenib stops the protein kinase. It has two way actions, 

1. Sorafenib will aim the protein which normally help to develop the malignant cells. 
2. Sorafenib helps to block cancer cells forming from new blood vessels.

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MyHep

MyHep - (SOFOSBUVIR TABLETS 400mg) 

DESCRIPTION

Myhep recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir, daclatasvir, or velpatasvir to cure genotype 1 to 6 infections. 

MYHEP (SOFOSBUVIR 400MG) Myhep (Sofosbuvir 400mg) is a prescription medicine used with other antiviral medicines to treat adults with chronic hepatitis C (Hep C) with or without cirrhosis (compensated). 

The half life of Myhep is 0.4 hours, and the half life of GS-331007 is 27 hours. Following a single 400 mg oral dose of Myhep , 80% is excreted in urine, 14% in feces, and 2.5% in expired air recovery. 

Therefore, inducers of intestinal P-glycoprotein, such as rifampicin and St. John's wort, could reduce the absorption of Myhep In addition, coadministration of Myhepwith anticonvulsants (carbamazepine, phenytoin, phenobarbital, oxcarbazepine), antimycobacterials (rifampin, rifabutin, rifapentine), and the HIV protease inhibitor tipranavir and ritonavir is expected to decrease Myhepconcentration.

 

Drug Interaction

The interaction between Myhep and a number of other drugs, such as ciclosporin, darunavir/ritonavir, efavirenz, emtricitabine, methadone, raltegravir, rilpivirine, tacrolimus, or tenofovir disoproxil, were evaluated in clinical trials and no dose adjustment is needed for any of these drugs..

Side Effects

Common side effects include feeling tired, headache, nausea, and trouble sleeping. Side effects are generally more common in interferon-containing regimens. Myhep may reactivate hepatitis B in those who have been previously infected. In combination with ledipasvir, daclatasvir or simeprevir it is not recommended with amiodarone due to the risk of an abnormally slow heartbeat.

Pregnancy 

Females who could potentially become pregnant should undergo a pregnancy test 2 months prior to starting the Myhep /ribavirin/peginterferon combination treatment, monthly throughout the duration of the treatment, and 6 months post-treatment to reduce the risk of fetal harm in case of accidental pregnancy. It is unknown whether Myhep and ribavirin pass into breastmilk; therefore, it is recommended that the mother does not breastfeed during treatment with Myhep alone or in combination with ribavirin.

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XBIRA - 250MG

Usage Of Xbira

Xbira is an inhibitor of CYP17 which is used to treats the patients with metastatic castration-resistant prostate cancer, The patient have received earlier chemotherapy with docetaxel combination with prednisone and in failure of androgen deprivation treatment.

The patient clinically not used for chemotherapy with prednisone or prednisolone will preferred treatment with metastatic CRPC in adult men.

 

Describes as

Xbira is a type of classification belongs to antineoplastics and it contain active ingredients of Abiraterone acetate. Which is an antiandrogen medication is indicated for the treatment of prostate cancer which spread to other parts of the body. Xbira is also used along with prednisone, a steroid. In clinical trials Xbira is used for prostate cancer and advanced breast cancer.

Mechanism of action

A type of steroidal enzyme inhibitor CYP17A1 (17 alpha-hydroxylase/C17,20 lyase) is known as abirateron acetate which is an orally active and It interefere with CYP17A1 in a selective and invariable manner through covalent binding mechanism. An enzyme CYP17A1 which catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. Particularily , abiraterone prevents the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to reduce serum levels of testosterone and other androgens.

Drug Interaction

→ Effects of Abiraterone on drug metabolizing enzymes
Abiraterone is a hepatic drug-metabolizing inhibitor CYP2D6, when substrates (dextromethorphan) of it is co administrated with Abiraterone will increases the Cmax and AUC dextromethorphan.
→ Drugs that inhibits or induce CYP3A4
Abiraterone interaction with strong CYP3A4inhibitors or inducers, the pharmacokinetics of Abiraterone is not evaluated properily, so avoid or use with caution while abiterone therapy.

Pregnancy

Category X: Abiraterone acetate is not recommended for womens, It will cause fetal harm when administered to pregnant women. During treatment if women become pregnant, immediately stop the drug and give counseling to the women.

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VOTRIENT (PAZOPANIB) - 400MG

Votrient

About Votrient

Votrient (pazopanib) is a type of protein kinase inhibitors. It is also indicated for the treatment of advanced kidney cancer and soft tissue sarcoma Votrient 400mg is an antineoplastics medications which interfere with the development and spreadness of cancer cells in the body..

Usage Of Votrient 400mg

Votrient 400mg is used as a single agent to treat the renel cell carcinoma and its advanced stage It works by preventing the activity of proteins which are interferes with the growth and spread of cancer cells. Votrient 400mg is also used as a single regimen to treat the Soft Tissue Sarcoma, (a type of cancer that occurs in the supportive tissue of the body). The cancer can develop in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs.

Votrient (Pazopanib) Mechanism Of Action

Votrient 400mg belongs to the classification of potent protein kinase inhibitor and selective multiple receptor tyrosine kinases (RTKs) which are define in beginning of signal transduction route that ready for multiplication of cancer cells and affect processes critical to cell survival and tumor breakthroughs . Stoppage of RTKs and includes the receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor.

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ENTEHEP 0.5 MG Online, Price, Price In India, Uses, Side Effects, Composition - MHP

Entehep-0.5mg

Introduction:

Entehep tablet, a antiviral drug which used for liver diseases, hepatitis B virus infected to HIV patients, liver infection. Entecavir is a film coated tablet. Entehep is an nucleotide polymerase analogue which used to treat the HBV, HCV, herpes simplex and HIV infections. When the drug is phosphorylated, they work as a antimetabolitie same to nucleotides to be confine into DNA strands growth, but they also act as chain terminators and stops the DNA viral polymerase.

Entecavir reduces the amount of HBV in the blood by decreasing the ability to replication and affects new cells.

Uses:

Entecavir, after liver transplantation the replication of HBV is prevented. X vir is used for the selected for resistance to lamivudine and emtricitabine in HIV, hence its not prescribed for both HIV-HBV patient without fully stopping X vir drug.

In adult and children < 2yrs, X vir mainly used for treatment of long lasting Hepatitis B infection. The infection caused by Hepatitis B virus in liver. This infection will damage the liver and cause liver failure or liver cancer. The reducing of hepatitis B virus quantity in body is carried out by X vir tablet.

Precaution

Pregnancy category C, pregnant women or planning for pregnancy and male sexual partner should inform doctor pirorly to usage of entehep because no appropriate and well defined studies of entehep in pregnant women. Similar for breast feeding. Unknown whether entehep excreted into human milk its affect adverse reaction for new born.

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SOVIHEP

DESCRIPTION

SOVIHEP(SOFOSBUVIR 400MG)  is a prescription medicine used with other antiviral medicines to treat adults with chronic hepatitis C (Hep C) with or without cirrhosis (compensated). Cure rates are 30 to 97% depending on the type of hepatitis C virus involved. Sovihep is safe and effective in patient who have had a liver transplant.

Sovihep(Sofosbuvir 400mg) is activated in the liver to the triphosphate GS-461203 by hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), and subsequent repeated phosphorylation.

Drug Interaction

The interaction between Sovihep and a number of other drugs, such as ciclosporin, darunavir/ritonavir, efavirenz, emtricitabine, methadone, raltegravir, rilpivirine, tacrolimus, or tenofovir disoproxil, were evaluated in clinical trials and no dose adjustment is needed for any of these drugs.

Side Effects

Common side effects include feeling tired, headache, nausea, and trouble sleeping. Side effects are generally more common in interferon-containing regimens.

 Sovihep may reactivate hepatitis B in those who have been previously infected. In combination with ledipasvir, daclatasvir or simeprevir it is not recommended with amiodarone due to the risk of an abnormally slow heartbeat.

Pregnancy

Pregnant women with hepatitis C who take ribavirin have shown some cases of birth defects and death in their fetus. It is recommended that Sovihep/ribarivin combinations be avoided in pregnant females and their male sexual partners in order to reduce harmful fetal defects caused by ribavirin.

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