MyHep
MyHep - (SOFOSBUVIR TABLETS 400mg)
DESCRIPTION
Myhep recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir, daclatasvir, or velpatasvir to cure genotype 1 to 6 infections.
MYHEP (SOFOSBUVIR 400MG) Myhep (Sofosbuvir 400mg) is a prescription medicine used with other antiviral medicines to treat adults with chronic hepatitis C (Hep C) with or without cirrhosis (compensated).
The half life of Myhep is 0.4 hours, and the half life of GS-331007 is 27 hours. Following a single 400 mg oral dose of Myhep , 80% is excreted in urine, 14% in feces, and 2.5% in expired air recovery.
Therefore, inducers of intestinal P-glycoprotein, such as rifampicin and St. John's wort, could reduce the absorption of Myhep In addition, coadministration of Myhepwith anticonvulsants (carbamazepine, phenytoin, phenobarbital, oxcarbazepine), antimycobacterials (rifampin, rifabutin, rifapentine), and the HIV protease inhibitor tipranavir and ritonavir is expected to decrease Myhepconcentration.
Drug Interaction
The interaction between Myhep and a number of other drugs, such as ciclosporin, darunavir/ritonavir, efavirenz, emtricitabine, methadone, raltegravir, rilpivirine, tacrolimus, or tenofovir disoproxil, were evaluated in clinical trials and no dose adjustment is needed for any of these drugs..
Side Effects
Common side effects include feeling tired, headache, nausea, and trouble sleeping. Side effects are generally more common in interferon-containing regimens. Myhep may reactivate hepatitis B in those who have been previously infected. In combination with ledipasvir, daclatasvir or simeprevir it is not recommended with amiodarone due to the risk of an abnormally slow heartbeat.
Pregnancy
Females who could potentially become pregnant should undergo a pregnancy test 2 months prior to starting the Myhep /ribavirin/peginterferon combination treatment, monthly throughout the duration of the treatment, and 6 months post-treatment to reduce the risk of fetal harm in case of accidental pregnancy. It is unknown whether Myhep and ribavirin pass into breastmilk; therefore, it is recommended that the mother does not breastfeed during treatment with Myhep alone or in combination with ribavirin.
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