Buy Xbira 250mg online|Apple pharmaceuticals

XBIRA - 250MG

Usage Of Xbira

Xbira is an inhibitor of CYP17 which is used to treats the patients with metastatic castration-resistant prostate cancer, The patient have received earlier chemotherapy with docetaxel combination with prednisone and in failure of androgen deprivation treatment.

The patient clinically not used for chemotherapy with prednisone or prednisolone will preferred treatment with metastatic CRPC in adult men.

 

Describes as

Xbira is a type of classification belongs to antineoplastics and it contain active ingredients of Abiraterone acetate. Which is an antiandrogen medication is indicated for the treatment of prostate cancer which spread to other parts of the body. Xbira is also used along with prednisone, a steroid. In clinical trials Xbira is used for prostate cancer and advanced breast cancer.

Mechanism of action

A type of steroidal enzyme inhibitor CYP17A1 (17 alpha-hydroxylase/C17,20 lyase) is known as abirateron acetate which is an orally active and It interefere with CYP17A1 in a selective and invariable manner through covalent binding mechanism. An enzyme CYP17A1 which catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. Particularily , abiraterone prevents the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to reduce serum levels of testosterone and other androgens.

Drug Interaction

→ Effects of Abiraterone on drug metabolizing enzymes
Abiraterone is a hepatic drug-metabolizing inhibitor CYP2D6, when substrates (dextromethorphan) of it is co administrated with Abiraterone will increases the Cmax and AUC dextromethorphan.
→ Drugs that inhibits or induce CYP3A4
Abiraterone interaction with strong CYP3A4inhibitors or inducers, the pharmacokinetics of Abiraterone is not evaluated properily, so avoid or use with caution while abiterone therapy.

Pregnancy

Category X: Abiraterone acetate is not recommended for womens, It will cause fetal harm when administered to pregnant women. During treatment if women become pregnant, immediately stop the drug and give counseling to the women.

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