Dasatinib - Sprycel tablet | Apple pharmaceuticals

DASATINIB

Dasatinib is used to treat a certain type of chronic myeloid leukemia. (CML; a type of cancer of the 

white blood cells) as a first treatment and in people who can no longer benefit from other leukemia 

medications including imatinib (Gleevec) or in those who cannot take these medications because of side effects.

The Brands are Available in  Dasatinib

1.Sprycel-20mg

2.Sprycel-50mg

3.Sprycel-70mg

Drug Type :

SPRYCEL is a targeted therapy. SPRYCEL is classified as a signal transduction inhibitor - tyrosine kinase inhibitor..

About Dasatinib : 

This medicine could also cause a sudden and significant fall in the count of white blood cells, red blood cells, or platelets, so you will be advised to assess your blood cell counts once every week for the first two months, and then once a month after that.

Indication of  Dasatinib :

For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.

Dasatinib Precautions : 

SPRYCEL interacts with many common medications. Be sure to notify your doctor before starting any new medications.

Do not receive any kind of immunization or vaccination without your doctor’s approval while taking SPRYCEL.

Dasatinib may harm the fetus.

Do not breastfeed while taking dasatinib and for 2 weeks after your final dose.

For more Information : 

Call us :  +91- 9987711567

Mail to : applepharmaceutical@gmail.com

Domain :  http://anti-cancer-drugs.com/dasatinib.php

Afatinib tablet - Apple pharmaceuticals

AFATINIB

DESCRIPTION :

Afatinib is used to treat metastatic non-small cell lung cancer (NSCLC) that has certain EGFR mutations (exon 19 deletion/exon 21 substitution) as detected by an FDA-approved test..

AFATINIB WORKS AS :

Afatinib is designed to block tumor cell growth in several ways. Afatinib blocks the activating sites (called tyrosine kinases) of several proteins within the cell. These proteins are most likely to stimulate cancer growth when the tumor contains the EGFR gene mutation. By blocking these targets, it is hoped the cancer will shrink.

Afatinib is not a chemotherapy drug but one of what are termed “targeted therapies.”

USES OF AFATINIB :

Afatinib is used to treat a certain type of lung cancer (non-small cell lung cancer) that has spread to other parts of the body. It belongs to a class of drugs known as kinase inhibitors.

FEATURES OF AFATINIB :

Afatinib oral tablet is available as a brand-name drug. It’s not available as a generic drug.  
Afatinib is used to treat non-small cell lung cancer. (NSCLC) that’s metastatic. Metastatic means the cancer has spread from your lungs to other parts of your body.

THE BRANDS ARE AVAILABLE IN AFATINIB : 

1. XOVOLTIB 20MG
2. XOVOLTIB 30MG
3. XOVOLTIB 40MG
4. XOVOLTIB 50MG

MECHANISM OF ACTION : 

Xovoltib 20mg,30mg,40mg,50mg  blocking the activating sites called tyrosine kinases of various proteins within the cell. These proteins are most likely to develop cancer growth when the tumor includes the EGFR gene mutation. By stopping these targets, it will target the cancer will shrink.

MISSED DOSE : 

If patient missed to take the dose of Xovoltib the missed dose should be skipped and follow the regular dosing schedule. Do not self-medicate. Do not double the dose.

FOR MORE INFORMATION :

Call us :  91-9987711567

Mail to : applepharmaaceutical@gmail.com

 

Domain :  https://myapplepharma.com/afatinib.php

Secukinumab tablet - Scapho | Blueberrypharmaceuticals

SECUKINUMAB

It is indicated for the treatment of patients with Plaque Psoriasis.

It is used to treat psoriasis, ankylosing spondylitis, and psoriatic arthritis It is given by subcutaneous..

injection and is sold in a pre-filled syringe or autoinjector that can be used at home and as a lyophilized powder for use in hospitals and clinics.

Indication

Scapho indicated for the treatment of following condition :

1.Psoriatic arthritis,

2.Plaque Psoriasis,

3.Ankylosing spondylitis.

Medication Prescribed For ;

Secukinumab injection is used to treat moderate to severe plaque psoriasis (a skin disease in which red,

 scaly patches form on some areas of the body) in people whose psoriasis is too severe to be treated by topical medications alone.

Mechanism of Action : 

Human IgG1 monoclonal antibody which selectively joins to and negate the pro inflammatory cytokine interleukin 17A (IL-17A)

IL-17A is a normallyappearing cytokine which is involved in normal inflammatory and immune responses and plays a key role 

in the pathogenesis of plaque psoriasis.

Precautions : 

Scapho may increase risk of infections; use with caution in patients with chronic infection or a history of recurrent infection 

Start with anti-TB therapy before to initiation of Secukinumab in patients with a history of latent or active TB in whom

an adequate course of treatment cannot be confirmed..

For More Infomation :

Call us :  +91-97890 77748
Mail to :  info@blueberrypharma.com
Domain : https://blueberrypharma.com/secukinumab.php

Denosumab - Prolia and Xgeva tablet | Apple pharmaceuticals

Denosumab

 Denosumab (trade names Prolia and Xgeva) is a 

 human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss,   metastases to bone, 

 and giant cell tumor of bone.

Denosumab is contraindicated in people with low blood calcium levels.

       The brands Available in Denosumab are: 

                                                        1.Prolia                                2. Xgeva

 Uses Of Denosumab Injection:

 To treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause (''change of life;''  end of menstrual periods) who have an increased risk for fractures (broken bones) or who cannot take or did not respond to other medication treatments for osteoporosis.

to treat bone loss in men who are being treated for prostate cancer with certain medications that cause bone loss,

to treat bone loss in women with breast cancer who are receiving certain medications that increase their risk for fractures..   

Drug Interaction 

No formal drug-drug interaction with denosumab during trials. 

When interacting with some anticancer drug, orthopedic drugs, vaccines will lead to risk of adverse effects can be increased.

Side-effects and risks

Common possible side-effects include:

• occasional skin infections (cellulitis) at the site of the injection
• back pain
• arm and leg pain
• urinary tract infections
• constipation
• rash.

Less common side-effects include:

low blood calcium – your blood levels will be checked before you start treatment.

For More Information

Call us :  +91- 9987711567

Mail to :   applepharmaceutical@gmail.com

Domain :   http://anti-cancer-drugs.com/denosumab.php

Alectinib | Alecensa capsule uses,side effects and cost

Alectinib

Alectinib is indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC).

Description

Alectinib belongs to second generation oral drug which selectively prohibits the  activity of  anaplastic lymphoma kinase (ALK) tyrosine kinase.It is part used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated 

protein-like 4)

 fusion protein that causes proliferation of NSCLC cells.

Alectinib Works as 

It is a tyrosine kinase inhibitor (TKI).Alectinib is a targeted therapy. TKI's block these cell signals and by blocking the signals,

they stop the growth of the cancer cells. TKI's are named based on the enzyme that they block.

Tyrosine kinases are specific enzymes (a type of protein) 

that may signal cancer cells

to grow. Alectinib blocks the abnormal ALK (anaplastic lymphoma kinase) protein.

How to given Alectinib tablets.

Take this medication with food.

If you miss a dose, take your next dose at your usually scheduled time. Do not take an extra dose to make up for a missed dose.

Do not repeat a vomited dose. Alectinib is a capsule, taken by mouth.

Swallow alectinib capsules whole. Do not open, crush or dissolve the capsules.The amount of alectinib 

that you will receive depends on many factors, your general health or other health problems, and the type of side effects that you may have. Your doctor will determine your exact dosage and schedule.

Precautions

For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking alectinib. Barrier methods of contraception, such as condoms, are recommended for up to 6 months after last dose of alectinib.

Do not breast feed while taking alectinib.

Do not receive any kind of immunization or vaccination without your doctor's approval while taking alectinib.

Embryo-fetal toxicity: Based on data from animal studies and its mechanism of action, alectinib can cause fetal harm when administered to pregnant women. 

For more information 

 

Call us :  +91–97890 77748

Mail to :  info@blueberrypharma.com

Domain :  https://blueberrypharma.com/alectinib.php

Dasatinib tablet uses,side effects,dose and cost | Blueberry Pharmaceuticals

Dasatinib  

Uses :

Dasatinib is also used to treat a certain type of chronic CML in children. Dasatinib is used to treat a certain type of chronic myeloid leukemia (CML; a type of cancer of the white blood cells) as a first treatment and in people who can no longer benefit from other leukemia medications including imatinib (Gleevec) or in those who cannot take these medications because of side effects.

Prescribed For

Dasatinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.Dasatinib is also used to treat a certain type of acute lymphoblastic leukemia (ALL; a type of cancer of the white blood cells) in people who can no longer benefit from other leukemia medications or who cannot take these medications because of side effects.

Precautions :

Before taking desatinib:

tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking dasatinib and for 30 days after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking dasatinib, call your doctor. Women who are pregnant should not handle crushed or broken dasatinib tablets. Dasatinib may harm the fetus.
do not breastfeed while taking dasatinib and for 2 weeks after your final dose.
you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking dasatinib.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking dasatinib.

How should this medicine be used?

Swallow the tablets whole; do not split, chew, or crush them. Wear latex or nitrile gloves when handling tablets that are accidently crushed or broken to prevent contact with the medication.
Your doctor may adjust your dose or permanently stop your treatment of dasatinib depending on your response to treatment and any side effects that you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take dasatinib even if you feel well. Do not stop taking dasatinib without talking to your doctor.

Swallow the tablets whole; do not split, chew, or crush them. Wear latex or nitrile gloves when handling tablets that are accidently crushed or broken to prevent contact with the medication.

For more Information

Call us : +91–97890 77748

Mail to : info@blueberrypharma.com

Domain : https://blueberrypharma.com/dasatinib.php

Gefitinib(iressa)| Geftinat 250mg | Gefticip 250mg | Gefitinib Tablet Price India

Gefitinib Tablets

Gefitinib tablets are categorized as kinase inhibitor, which exhibits anti-cancer activity by undergoing mechanism like protein kinase inhibition, the main ingredient which is used as Gefitinib Iressa. Gefitinib which is chemically known as anilinoquinazoline which contains anti-neoplastic effects..

Available brands in Gefitinib are:

INDICATION

Gefitinib is considered as first line therapy in non-small cell lung carcinoma in metastatic stage, tumor cell containing epidermal growth factor receptors like exon 19 deletion or exon 21 substitution mutations which is identified by FDA approved test.

The mean bioavailability of Gefitinib is 60% The peak plasma concentration time of Gefitinib Iressa is reaches within 3 to 7 hours after drug intake Gefitinib is distributed throughout the body and causes steady state volume of distribution in 1400L The human plasma protein bound of Gefitinib Iressa is occurs as 90%. The metabolism of Gefitinib is occurs through hepatically, by using CYP3A4. Three sections of biotransformation occurs in metabolism of Gefitinib includes as; 1. Metabolism of N-propoxymorpholino group 2. Methoxy substituent on quinazoline demethylation occur 3. Halogenated phenyl group undergoes oxidative defluorination The major active metabolite of Gefitinib is O desmethyl Gefitinib Iressa which is formed by CYP2D6 metabolism. Gefitinib is cleared away with the help of liver, with half life elimination occurring within 48 hours. The steady state plasma concentration is accomplished within 10 days after daily single dose. The elimination of Gefitinib is occurs through feces with the range of 86% and renal elimination also occurred with less than 4%.

OVER DOSAGE

There is no distinct therapy for over dosage of Gefitinib, if over dosage occurs provide supportive care and monitor the patients frequently for the signs and symptoms of over dosage of Gefitinib Iressa.

For More Information

Call Us

+91-97890 77748

Mail to

info@blueberrypharma.com

Domain : https://blueberrypharma.com/gefitinib.php